In an MMA fight, Jake Paul would likely have the advantage over Mike Tyson due to his youth, conditioning, and familiarity with modern training methods. Jake Paul is 27 and actively competing, whereas Mike Tyson, at 58, is well past his physical prime despite his legendary boxing career.
While Tyson's boxing skills and raw power are iconic, MMA incorporates grappling, kicks, and submissions, areas where Tyson has little to no experience. Additionally, age plays a significant role in combat sports; reaction time, endurance, and recovery are drastically diminished in later years.
So, Jake Paul would most likely win in this hypothetical MMA fight.